Unilateral deafness with vestibular dysfunction / DINGS1 (PTPRQ-related) - Doberman Pinscher

DINGS1 in Doberman Pinschers

This genetic test detects the PTPRQ c.9230_9231insA variant that causes unilateral deafness with vestibular dysfunction. In Doberman Pinschers the condition is also known as DINGS1, one-sided deafness with balance problems or an inherited inner-ear disorder.

What does this mean for the dog?

PTPRQ is important for the function of sensory hair cells in the inner ear. Affected puppies can show one-sided deafness and clear balance problems from a young age, such as head tilt, circling, ataxia or poor coordination.

Practical value of this test

• Identifies clear dogs, carriers and genetically affected dogs.
• Helps breeders avoid carrier-to-carrier matings and reduce the risk of affected puppies.
• Provides early genetic clarity in Doberman lines where deafness and vestibular signs are a concern.

Inheritance and result

DINGS1 caused by this PTPRQ variant follows an autosomal recessive inheritance pattern. Dogs with N/N do not carry the variant, N/insA dogs are carriers and insA/insA causes the tested form of the disorder.