Spinal muscular atrophy / SMA (LIX1/LNPEP deletion) - Cat

Spinal muscular atrophy in cats

This genetic test detects the large LIX1/LNPEP deletion that causes spinal muscular atrophy (SMA) in cats. SMA is an inherited neuromuscular disorder affecting motor neurons. It leads to progressive muscle weakness, tremor and muscle atrophy, most visibly affecting gait and the hindquarters.

What can owners or breeders notice?

Signs are typically seen at a young age. Cats may develop an abnormal gait, wide-set forelimbs, a swaying pelvic movement, tremors and increasing muscle weakness. The DNA test identifies the underlying deletion before breeding combinations are planned.

Practical value of this test

• Clear: the cat does not carry the tested deletion and will not pass it on.
• Carrier: the cat carries one copy; it is not genetically affected but can pass the deletion to offspring.
• Affected: the cat carries two copies; this genotype causes SMA.

Inheritance

SMA caused by this LIX1/LNPEP deletion follows an autosomal recessive inheritance pattern. The test is useful for breeding selection, avoiding carrier-to-carrier matings and interpreting neurological or muscle-related signs.