Sebaceous gland dysplasia (SOAT1-related) - Cat

Sebaceous gland dysplasia in cats

This genetic test detects the SOAT1 c.1531G>A variant that causes SOAT1-related sebaceous gland dysplasia in cats. The condition is also known as sebaceous gland dysplasia and belongs to the inherited skin disorders in which sebaceous glands develop abnormally and normal skin and coat quality are disturbed.

What does this mean for skin and coat?

Affected kittens may develop a thin or poor coat, dark crusting around the eyes, nose and ears, crusting on the legs, scaling and local hair loss. Because sebum supports the skin barrier, hair follicles and eyelid margins, an SOAT1 defect can produce several visible skin and coat signs.

Practical value of this test

• Clear: the cat does not carry the tested variant and will not pass it on.
• Carrier: the cat carries one copy; it is not genetically affected but can pass the variant to offspring.
• Affected: the cat carries two copies; this genotype causes SOAT1-related sebaceous gland dysplasia.

Inheritance

This SOAT1-related form of sebaceous gland dysplasia follows an autosomal recessive inheritance pattern. The test helps breeders identify carriers, plan matings more confidently and reduce the risk of affected kittens.