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40
The r1 mutation in the LIPH gene causes the rex coat in rabbits, characterized by a soft, plush fur due to shortened guard hairs.
Overview
The r1 mutation in rabbits is associated with the characteristic rex coat phenotype. This phenotype is defined by a soft, dense, and velvety fur texture, which differs clearly from the normal rabbit coat.
The mutation is located in the LIPH gene (lipase, member H), a gene involved in the development and structure of hair follicles. At the molecular level, the r1 variant consists of a single nucleotide deletion in exon 9, which disrupts the normal function of the protein.
As a result, the structure of the hair is altered. In affected rabbits, the guard hairs are shortened and become similar in length to the undercoat. This leads to the typical plush and upright coat structure seen in rex rabbits, with a uniform and soft appearance.
The r1 mutation is one of several known genetic variants associated with the rex phenotype in rabbits.
Included subanalyses
This analysis includes the following subanalysis:
Phenotypes
Allele combinations & result interpretations
Sampling and submission guidelines
References
