Progressive retinal atrophy / rdy-PRA / rod-cone dysplasia (CRX-related) - Cat

rdy-PRA / rod-cone dysplasia in cats

This DNA test assesses the CRX variant c.546del that causes rdy-PRA / rod-cone dysplasia. The disorder is also known as Rdy, rdy-PRA, rod-cone dysplasia, cone-rod dystrophy/dysplasia, progressive retinal dystrophy and progressive retinal atrophy. It is an inherited retinal disorder in which rod and cone development and function are disrupted.

Cats with one copy can show signs within the first weeks of life, including delayed pupil responses, nystagmus and early retinal changes. Two copies cause a more severe form with marked disruption of photoreceptor development.

How to read the result

• Clear: the tested CRX deletion is not detected; the cat will not pass on this variant.
• One copy: one copy causes rdy-PRA and is already genetically relevant for visual development and breeding plans.
• Two copies: two copies cause a more severe form with marked disruption of photoreceptor development.

Practical value of this test

• distinguishes clear cats, cats with one copy and cats with two copies;
• provides clear information for matings where early retinal disease should be avoided;
• helps breeders select more precisely in lines where rdy-PRA occurs.