Progressive ataxia / PA (KIF1C-related) - Cattle

Progressive ataxia in cattle

This DNA test detects the KIF1C variant c.608G>A that causes progressive ataxia, also described as Charolais ataxia, progressive ataxia of Charolais and in OMIA within congenital hypomyelinogenesis. The disorder affects myelin support of nerve pathways in the brain and spinal cord.

Affected animals develop incoordination, an unsteady gait, stiff hind limbs and eventually severe movement problems. Signs can appear in young adult cattle and often worsen gradually.

Inheritance and meaning

Progressive ataxia is inherited as an autosomal recessive disorder. Carriers have one copy of the variant and usually remain free of disease signs, but pass the variant to part of their offspring. Two copies cause progressive ataxia.

Practical value of this test

• Carrier detection: select breeding animals with clear knowledge of their KIF1C status.
• Avoid affected calves: prevent carrier-to-carrier matings.
• Breed management: use valuable carrier animals responsibly by pairing them with clear animals.