Polyneuropathy / LPN2 (GJA9-related) - Leonberger

What does this test analyse?

This genetic test analyses the GJA9 c.1107_1108delAG variant for polyneuropathy / LPN2 in the Leonberger. GJA9 encodes a connexin protein; the tested frameshift deletion disrupts normal protein function.

What does this condition mean?

LPN2 is a form of polyneuropathy in Leonberger dogs in which peripheral nerves are progressively damaged. Affected dogs can develop weakness, muscle atrophy, breathing difficulties and a changed bark or voice. Because this variant is autosomal incompletely dominant, one copy is already relevant for genetic interpretation and breeding plans.

Inheritance and result

The trait is inherited as an autosomal incomplete dominant condition. Heterozygous dogs already have a positive genetic result. Homozygous dogs carry two copies and should be read as genetically highly loaded.

Practical value of this test

• Shows directly whether a Leonberger carries the LPN2 variant.
• Helps breeders avoid passing on or accumulating the variant unnecessarily.
• Distinguishes a clear dog, a heterozygous positive dog and a homozygous positive dog.
• Supports interpretation in lines with weakness, muscle loss, breathing problems or voice change.
• Helps manage LPN2 alongside other Leonberger polyneuropathies such as LPN1 and LPPN3.