Polyneuropathy / AMPN (NDRG1-related) - Alaskan Malamute

What does this test analyse?

This genetic test analyses the NDRG1 c.293G>T variant for polyneuropathy / AMPN in the Alaskan Malamute. NDRG1 is important for normal Schwann-cell and myelin function in peripheral nerves.

What does this condition mean?

AMPN is an inherited polyneuropathy affecting peripheral nerves and myelin. Affected dogs can develop exercise intolerance, abnormal gait, hindlimb weakness, muscle loss, voice change, noisy breathing or laryngeal involvement at a young age. The condition is also described as Alaskan Malamute polyneuropathy, hereditary polyneuropathy and a Charcot-Marie-Tooth-like neuropathy model.

Inheritance and result

The trait is inherited as an autosomal recessive condition. Clear dogs have two normal copies. Carriers have one copy of the variant and can pass it on. Dogs with two copies have the genotype that causes AMPN.

Practical value of this test

• Identifies carriers before two carriers are combined.
• Helps avoid affected puppies without automatically removing healthy carriers from valuable lines.
• Gives breeders clear information for pedigree planning, import/export decisions and mate selection.
• Supports owners when young dogs develop weakness, abnormal gait or noisy breathing.
• Enables targeted reduction of the variant frequency within lines.