DNA & genetic tests
Pricing
Incl. VAT

48.4

Excl. VAT

40

Polydactyly / extra toes 3 variants (LMBR1/ZRS) - Cat

DNA panel for three LMBR1/ZRS variants that cause polydactyly or extra toes in cats.

Turnaround time
10 workdays
test Methods
Sequencing
Test code
PVT-ACC1F0A31B53
Species
Cat
Matrices
Blood, Blood (EDTA), Blood (Heparin), Swab, Tissue

Overview

Polydactyly in cats

This genetic test examines three variants in the ZRS enhancer within the LMBR1 region: Hw, UK1 and UK2. These regulatory variants affect SHH control during limb development and can cause polydactyly, also known as extra toes, preaxial polydactyly or the Hemingway mutation for the Hw variant.

What does polydactyly mean?

Cats normally have 18 toes. In polydactyly, kittens are born with more toes than usual, most often on the front paws but sometimes also on the hind paws. The number and shape of the extra toes can differ between cats. The trait is usually not painful and is mainly regarded as an anatomical feature in cats.

Why this test is useful

  • The test shows whether the cat carries one of the three known LMBR1/ZRS variants.
  • The result helps breeders manage extra-toe lines in a targeted way.
  • A negative result does not fully exclude other, currently untestable causes of polydactyly.

Polydactyly is inherited as autosomal dominant. One copy of a tested variant can already cause extra toes, but expression and toe number can vary.

Included subanalyses

This analysis includes the following subanalyses:

  • Polydactyly Hw / Hemingway (LMBR1/ZRS)
  • Polydactyly UK1 (LMBR1/ZRS)
  • Polydactyly UK2 (LMBR1/ZRS)

Allele combinations & result interpretations

Sampling and submission guidelines

References