Turnaround time
10 workdays
48.4
40
DNA panel for three LMBR1/ZRS variants that cause polydactyly or extra toes in cats.
Overview
This genetic test examines three variants in the ZRS enhancer within the LMBR1 region: Hw, UK1 and UK2. These regulatory variants affect SHH control during limb development and can cause polydactyly, also known as extra toes, preaxial polydactyly or the Hemingway mutation for the Hw variant.
Cats normally have 18 toes. In polydactyly, kittens are born with more toes than usual, most often on the front paws but sometimes also on the hind paws. The number and shape of the extra toes can differ between cats. The trait is usually not painful and is mainly regarded as an anatomical feature in cats.
Polydactyly is inherited as autosomal dominant. One copy of a tested variant can already cause extra toes, but expression and toe number can vary.
Included subanalyses
This analysis includes the following subanalyses:
Allele combinations & result interpretations
Below, for each tested locus, you will find the possible allele combinations that may be reported within this analysis, together with a brief explanation of their genetic meaning. The interpretation of possible interactions between different loci is included in the report, but is not shown here in full because that would lead to too many combinations on this page. The final expression may also depend on other genes and their interaction.
Genotype / allele combination: Variant not detected
The tested Pd^Hw variant was not detected. This cat will not pass this specific variant on; other polydactyly variants remain possible.
Genotype / allele combination: Variant present, one copy
This cat carries one copy of Pd^Hw. One copy can cause polydactyly and can pass extra-toe predisposition to offspring; expression and toe number can vary.
Genotype / allele combination: Variant present, two copies
This cat has two copies of Pd^Hw. The variant is present in double dose and can cause polydactyly; two copies do not reliably predict more extra toes than one copy.
Genotype / allele combination: Variant not detected
The tested Pd^UK1 variant was not detected. This cat will not pass this specific variant on; other polydactyly variants remain possible.
Genotype / allele combination: Variant present, one copy
This cat carries one copy of Pd^UK1. One copy can cause polydactyly and can pass extra-toe predisposition to offspring; expression and toe number can vary.
Genotype / allele combination: Variant present, two copies
This cat has two copies of Pd^UK1. The variant is present in double dose and can cause polydactyly; two copies do not reliably predict more extra toes than one copy.
Genotype / allele combination: Variant not detected
The tested Pd^UK2 variant was not detected. This cat will not pass this specific variant on; other polydactyly variants remain possible.
Genotype / allele combination: Variant present, one copy
This cat carries one copy of Pd^UK2. One copy can cause polydactyly and can pass extra-toe predisposition to offspring; expression and toe number can vary.
Genotype / allele combination: Variant present, two copies
This cat has two copies of Pd^UK2. The variant is present in double dose and can cause polydactyly; two copies do not reliably predict more extra toes than one copy.
Sampling and submission guidelines





References