Polioencephalopathy / PE (MECR-related) - Eurasier

What does this test examine?

This genetic test analyses the MECR c.823A>G variant for polioencephalopathy, abbreviated as PE, in Eurasiers. MECR encodes mitochondrial trans-2-enoyl-CoA reductase, a protein involved in normal mitochondrial metabolism. The variant has been described in Eurasier puppies with a progressive neurological condition affecting mainly the grey matter of the brain.

What does polioencephalopathy mean?

Polioencephalopathy is a serious neurological disorder. Affected puppies can show early movement abnormalities such as ataxia, unsteady gait, exaggerated limb movement, spasms, dystonia or strabismus. In the described cases, consciousness and behaviour were often relatively preserved while motor problems progressed. Early genetic recognition is therefore useful for breeding decisions and for managing puppies from lines where the variant is present.

Inheritance and result

The test is interpreted in an autosomal recessive model. The variant has been described as possibly causative, so the result should be clear but not overstated. Dogs with two copies have the risk genotype for this MECR-related PE form. Dogs with one copy are carriers and can pass the variant on without showing the classic condition.

• Clear: the tested variant was not detected.
• Carrier: one copy is present; the dog can pass the variant on.
• Risk genotype: two copies are present and indicate a clear genetic risk for the described PE phenotype.

Practical value of this test

For Eurasier breeders, the test helps identify carriers before a mating is planned. This supports combinations in which puppies with two copies are avoided. For owners and veterinarians, the result can add genetic clarity when young dogs show neurological signs, movement episodes or progressive motor dysfunction.