PKD / Polycystic kidney disease type 1 (PKD1-related) - Cat

PKD / polycystic kidney disease type 1 in cats

This genetic test examines the PKD1 variant c.9882C>A. The condition is also known as PKD, polycystic kidney disease, ADPKD, autosomal dominant polycystic kidney disease. Affected cats develop multiple kidney cysts. These cysts put pressure on healthy kidney tissue and can gradually cause loss of kidney function. Clinical signs can include increased drinking and urination, reduced appetite, weight loss, vomiting, lethargy and kidney failure.

What is tested?

• The gene: PKD1.
• The variant: c.9882C>A.
• The inheritance pattern: autosomal dominant; two copies of the variant are described as likely homozygous lethal.
• The scope: breeds with PKD1 risk, including Persian-derived and several other cat breeds.

Practical value of this test

The result shows whether the cat carries the PKD1 variant. For breeders, this helps manage PKD deliberately within lines and avoid higher-risk matings. For owners, the result gives valuable information for early recognition, planning and follow-up of cats with genetically increased PKD risk.