Paroxysmal exercise-induced dyskinesia / PED (TNR-related) - Weimaraner

What does this test examine?

This genetic test analyses the TNR variant c.831dupC in the Weimaraner. The condition is known as Paroxysmal exercise-induced dyskinesia / PED and related clinical names used for this disorder.

The tested TNR duplication causes a frameshift and strongly truncates tenascin-R, a protein important in the nervous system.

What does this condition mean?

Affected Weimaraners can develop puppy-onset episodes with abnormal gait, hypermetria, dystonia, ataxia, kyphosis, low head carriage and sometimes collapse. Episodes are often triggered by exercise or excitement.

For breeders and owners, this type of DNA test is especially valuable because carriers can look healthy. Without DNA results, two carriers may be paired unintentionally and produce puppies with a serious disorder.

Inheritance and result

The trait is autosomal recessive. A clear dog does not carry the variant, a carrier has one copy and a dog with two copies is genetically affected for this tested form.

Practical value of this test

• The result shows whether the dog is clear, carrier or genetically affected for the tested variant.
• Breeders can identify carriers and avoid matings that can produce affected puppies.
• The test gives early certainty before sale, breeding use or mating plans.
• Carriers can remain in breeding responsibly when paired with clear partners, helping preserve genetic diversity.
• The test is useful for planning Weimaraner matings and preventing puppies with exercise-induced movement episodes.