Paroxysmal dyskinesia / PD (PIGN-related) - Irish Soft Coated Wheaten Terrier

What does this test examine?

This genetic test analyses the PIGN variant c.398C>T in the Irish Soft Coated Wheaten Terrier. The condition is known as Paroxysmal dyskinesia / PD and related clinical names used for this disorder.

The tested PIGN missense variant changes an amino acid in a gene involved in GPI-anchor biosynthesis and normal nerve function.

What does this condition mean?

Affected dogs can develop episodes from young adulthood with rapid flexion and extension movements, especially in the hind limbs. Episodes can last minutes to hours and may be triggered by stress, excitement or noise.

For breeders and owners, this type of DNA test is especially valuable because carriers can look healthy. Without DNA results, two carriers may be paired unintentionally and produce puppies with a serious disorder.

Inheritance and result

The trait is autosomal recessive. A clear dog does not carry the variant, a carrier has one copy and a dog with two copies is genetically affected for this tested form.

Practical value of this test

• The result shows whether the dog is clear, carrier or genetically affected for the tested variant.
• Breeders can identify carriers and avoid matings that can produce affected puppies.
• The test gives early certainty before sale, breeding use or mating plans.
• Carriers can remain in breeding responsibly when paired with clear partners, helping preserve genetic diversity.
• The result helps Wheaten Terrier breeders keep an episodic neurological disorder out of breeding plans in a targeted way.