Nonsyndromic hearing loss / deafness (LOXHD1-related) - Rottweiler

What does this test analyse?

This genetic test analyses the LOXHD1 c.5747G>C variant in the Rottweiler. The condition is also described as nonsyndromic hearing loss, nonsyndromic deafness and LOXHD1-related deafness. LOXHD1 is involved in inner-ear function; disruption of this pathway can affect hearing without necessarily causing other visible abnormalities.

What does this condition mean?

In recessive LOXHD1-related deafness, dogs with two copies of the tested variant are genetically affected. They may develop congenital or early-onset hearing loss. Carriers have one copy of the variant and are usually not deaf because of this variant, but they can pass it on to offspring.

Practical value of this test

This test is particularly useful for Rottweiler breeders who want to actively reduce inherited deafness risk in their lines. The result shows whether a dog is clear, a carrier or genetically affected for the tested variant, making mating decisions more transparent and reducing the risk of affected puppies.

• Identifies hidden carriers before breeding.
• Supports safer pairing decisions between breeding dogs.
• Provides clear information for puppy buyers, breeding advice and health planning.

Inheritance and result

This trait is inherited as an autosomal recessive condition. A dog with GG does not carry the tested variant. A dog with GC is a carrier. A dog with CC has two copies of the variant and is genetically affected for this LOXHD1-related form of hearing loss.