Myosin-heavy chain myopathy / MYHM (MYH1-related) - Horse

DNA test for the MYH1 c.959A>G / E321G variant that causes susceptibility to MYHM in Quarter Horse-related breeds.

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Turnaround time

10 workdays

test Methods

Sequencing

Test code

PVT-BF707151ACE9

Species

Horse

Breeds

American Paint, American Quarter Horse, Appaloosa, Belgian Draft, Welsh Pony

Matrices

Blood, Blood (EDTA), Blood (Heparin), Hair, Semen, Swab, Tissue

Overview

MYHM in Quarter Horse-related breeds

This genetic test detects the MYH1 variant c.959A>G / E321G for myosin-heavy chain myopathy, abbreviated MYHM. The condition is also linked with immune-mediated myositis and non-exertional rhabdomyolysis.

MYHM affects skeletal muscle. Susceptible horses can develop muscle loss, stiffness, weakness, swelling, pain, reduced performance or episodes of muscle breakdown. Triggers such as infection, vaccination, stress or training can influence the clinical picture.

Practical value of this test

N/N: the tested MYH1 variant is not detected.
N/My: one copy causes MYHM susceptibility and can be passed on.
My/My: two copies cause MYHM susceptibility and can create a higher genetic load.

The test supports breeding selection, recognition of susceptible horses and more targeted management around training, illness and other possible triggers.

Included subanalyses

This analysis includes the following subanalysis: