Lundehund syndrome / intestinal lymphangiectasia (P3H2-related) - Lundehund

What does this test analyse?

This genetic test analyses the P3H2 c.1849G>C variant in the Lundehund. The condition is named Lundehund syndrome, LS and intestinal lymphangiectasia.

The variant is used as a genetic risk factor for a gastrointestinal disease involving protein loss through the intestine.

What does this condition mean?

Lundehund syndrome can cause recurrent diarrhoea, vomiting, weight loss, oedema, lethargy, malabsorption and low blood protein values. Severity can differ strongly between animals.

Inheritance and result

This variant is used practically as a genetic risk factor. Two copies indicate increased genetic risk; one copy is mainly important for breeding plans and variant status within a line.

Practical value of this test

• The test distinguishes clear dogs, carriers and genetically affected or risk-positive dogs.
• The result helps breeders plan matings and avoid risk pairings.
• Variant status can be documented clearly within lines, families and breeding advice.
• The result helps breeders recognise risk genotypes and carriers more clearly within the small Lundehund population.
• The test supports mating plans and adds context for dogs from lines with gastrointestinal problems.

Because this is a risk factor and the clinical picture can be variable, the result is mainly intended to guide genetic risk assessment and breeding plans.