Long QT syndrome / LQTS (KCNQ1-related) - English Springer Spaniel

What does this test examine?

This genetic test analyses the KCNQ1 variant c.770C>A in the Engelse Springer Spaniël. The condition is known as Lang QT-syndroom / LQTS, also called LQTS, long QT syndrome and KCNQ1-related arrhythmia.

Long QT syndrome affects the electrical recovery phase of the heart. Dogs with the variant can develop a prolonged QT interval and may be at risk of fainting, serious arrhythmia or sudden death.

Practical value of this test

• makes an inherited heart-rhythm risk visible at the DNA level;
• helps breeders avoid unintentionally passing on the dominant variant;
• supports targeted selection in English Springer Spaniels with relevant family history;
• gives owners and veterinarians clear context when fainting or rhythm signs occur.

Who benefits from this test?

Genetic clarity is especially valuable for this condition because early visible signs may be limited while the consequences can be severe. A DNA result helps evaluate breeding dogs, relatives and offspring more consistently.

• for breeders who want to know inherited risks before planning a mating;
• for owners who want clarity about their dog’s genetic status;
• for veterinarians and breed clubs who want structured breed-health information;
• for puppy buyers who value transparent inherited-health information within a line.

Inheritance and result meaning

The trait is inherited as an autosomal dominant disorder: one copy of the variant is sufficient to cause disease risk. Use this result actively for breeding planning and risk management.