Ligneous membranitis / plasminogen deficiency (PLG-related) - Scottish Terrier

What does this test analyse?

This genetic test analyses the PLG c.1256+2T>A variant in the Scottish Terrier. The condition is named ligneous membranitis, LM and plasminogen deficiency.

PLG encodes plasminogen, a protein important for fibrin breakdown and mucosal repair.

What does this condition mean?

Affected dogs can develop thick, wood-like membranes and inflammation involving the eyes, mouth, throat, airways and other mucous membranes. In young dogs this may be severe, with chronic conjunctivitis, nasal discharge, coughing, scarring and general deterioration.

Inheritance and result

The trait is inherited as autosomal recessive. One copy makes a dog a carrier; two copies cause the genetically affected genotype.

Practical value of this test

• The test distinguishes clear dogs, carriers and genetically affected or risk-positive dogs.
• The result helps breeders plan matings and avoid risk pairings.
• Variant status can be documented clearly within lines, families and breeding advice.
• In family lines with LM, the test helps avoid carrier-to-carrier pairings and plan healthy selection more deliberately.
• The result is especially valuable when a dog is related to lines in which mucosal problems or LM have been identified.

Because this is a breed-linked variant, the result is most valuable in Scottish Terriers and related breeding lines where this variant is relevant.