Leukoencephalomyelopathy / LEMP (NAPEPLD-related) - Leonberger

What does this test examine?

This genetic test analyses the NAPEPLD c.538G>C variant in the Leonberger. The condition is described as leukoencephalomyelopathy, LEMP and NAPEPLD-related white matter disease.

What does this condition mean?

LEMP is a severe disorder of the white matter in the central nervous system. Dogs can develop progressive gait abnormalities, knuckling, paw dragging, hypermetria, ataxia and increasing mobility restriction.

Practical value of this test

• The result shows whether the dog is clear, a carrier or genetically affected for the tested variant.
• Breeders can identify carriers and avoid combinations that can produce affected puppies.
• In breeds where the variant occurs, DNA testing helps identify risk before clinical signs or breeding problems arise.
• For Leonberger breeders, the test helps identify carriers and risk genotypes early and plan combinations that strongly reduce the chance of affected offspring.

Inheritance and interpretation

The trait is inherited in an autosomal recessive manner. One copy means carrier status. Two copies mean the genotype interpreted as affected or high risk for this disorder in the known breed context.