Leukodystrophy / SLEM (CYTB-related, mitochondrial) - Dog

What does this test examine?

This genetic test analyses the mitochondrial CYTB c.14474G>A variant. The condition is described as leukodystrophy, SLEM, canine spongiform leukoencephalomyelopathy and Shetland Sheepdog leukodystrophy.

What does this condition mean?

Progressive neurological signs such as ataxia, tremor, weakness, loss of coordination and increasing movement problems.

Practical value of this test

• The result shows whether the dog is clear, a carrier or genetically affected for the tested variant.
• Breeders can identify carriers and avoid combinations that can produce affected puppies.
• In breeds where the variant occurs, DNA testing helps identify risk before clinical signs or breeding problems arise.
• Because mitochondrial DNA is transmitted through the maternal line, this test is especially valuable for females and maternal lines.

Inheritance and interpretation

This trait follows mitochondrial maternal inheritance. It is therefore not interpreted as classic autosomal carrier status; the result indicates whether the tested mitochondrial variant is detected or not detected.