Lavender foal syndrome / LFS (MYO5A-related) - Horse

What does this test examine?

This genetic test examines the MYO5A deletion that causes lavender foal syndrome. The condition is also known as Lavender Foal Syndrome, LFS, coat colour dilution lethal and a neonatal neurological syndrome in Arabian horses.

What does lavender foal syndrome mean?

LFS is a severe autosomal recessive disorder in newborn foals. Affected foals often have a distinctive diluted, silvery or lavender-like coat colour and severe neurological signs. Typical signs include inability to stand or nurse, opisthotonus, muscle spasms, seizure-like episodes and severe coordination problems. The condition is fatal.

Practical value of this test

• The test detects the known MYO5A deletion for LFS.
• Carriers are healthy themselves, but can pass the variant on.
• Breeders can avoid carrier x carrier matings and prevent affected foals.
• The result is especially useful in Arabian and Anglo-Arabian lines where LFS can occur.

Inheritance and result

LFS is inherited as an autosomal recessive disorder. A horse with one copy is a carrier. A foal with two copies develops LFS; this causes a fatal neurological disease shortly after birth.