Late onset ataxia / spinocerebellar ataxia / SCA (CAPN1-related) - Russell Terriers

What does this test examine?

This genetic test analyses the CAPN1 variant c.344G>A in the Jack Russell Terrier en Parson Russell Terrier. The condition is known as late onset ataxie / SCA, also called LOA, late onset ataxia, spinocerebellar ataxia, hereditary ataxia and SCA.

This form of ataxia causes increasing disturbance of coordination and movement. In Russell Terriers, the hindquarters can become especially uncoordinated, with a dancing or prancing gait.

Practical value of this test

• identifies carriers before two carriers are mated;
• helps breeders actively manage neurological risk in Russell lines;
• distinguishes CAPN1-related ataxia from other ataxia forms in the same breed group;
• supports transparent information for puppy buyers and breed clubs.

Who benefits from this test?

This test is especially useful because ataxia in Russell Terriers can be genetically heterogeneous. A targeted CAPN1 test gives concrete information for selection, line management and avoiding affected puppies.

• for breeders who want to know inherited risks before planning a mating;
• for owners who want clarity about their dog’s genetic status;
• for veterinarians and breed clubs who want structured breed-health information;
• for puppy buyers who value transparent inherited-health information within a line.

Inheritance and result meaning

The condition is inherited as an autosomal recessive disorder: two copies cause disease, while one copy means carrier status. By pairing carriers with clear-tested partners, the variant can be managed responsibly.