Laryngeal paralysis and polyneuropathy / LPPN3 (CNTNAP1-related) - Dog

What does this test examine?

This genetic test analyses the CNTNAP1 variant c.2810G>A in the hond. The condition is known as larynxparalyse en polyneuropathie / LPPN3, also called LPPN3, laryngeal paralysis and polyneuropathy and CNTNAP1-related neuropathy.

LPPN3 combines airway problems from laryngeal paralysis with signs of polyneuropathy. Dogs may breathe noisily, have difficulty swallowing, develop an altered bark and progressively move more unsteadily or weakly.

Practical value of this test

• identifies carriers before two risk lines are combined;
• helps breeders plan healthy matings in large and giant breeds;
• makes neurological and breathing signs easier to interpret within an inherited context;
• supports transparent communication about LPPN3 status in breeding lines.

Who benefits from this test?

This analysis is useful for breeders of breeds in which the CNTNAP1 variant is described, especially where airway and nervous-system problems occur in a line. A clear DNA result helps use carriers responsibly without increasing the risk of affected puppies.

• for breeders who want to know inherited risks before planning a mating;
• for owners who want clarity about their dog’s genetic status;
• for veterinarians and breed clubs who want structured breed-health information;
• for puppy buyers who value transparent inherited-health information within a line.

Inheritance and result meaning

LPPN3 is inherited as an autosomal recessive disorder: two copies cause disease, while one copy means carrier status. By pairing carriers only with clear-tested partners, the variant can be managed in a controlled way.