Juvenile dilated cardiomyopathy / JDCM (ABCC9-related) - Manchester Terrier

What does this test analyse?

This genetic test analyses the ABCC9 c.3557G>A variant in Manchester Terriers. The condition is known as juvenile dilated cardiomyopathy, JDCM, dilated cardiomyopathy, DCM and sudden cardiac death in the young. ABCC9 encodes part of a cardiac ATP-sensitive potassium channel that is important for electrical and metabolic stability of the heart muscle.

What does this heart condition mean?

In dilated cardiomyopathy, the heart muscle contracts less effectively and the left ventricle can become enlarged. The juvenile form in Manchester Terriers can be severe: puppies and young dogs may appear healthy but still develop heart failure, fatal rhythm disturbance or sudden death. Reported signs include rapid or strained breathing, restlessness, weakness, reduced appetite, vomiting, pale gums and sudden death, often at a young age.

Inheritance and result

This form is autosomal recessive. One copy makes a dog a carrier. Two copies of the tested ABCC9 variant cause the tested JDCM genotype.

Result at a glance

• G/G - the tested variant was not detected.
• G/A - carrier; one copy of the variant is present.
• A/A - two copies of the variant; this genotype causes the tested recessive form of JDCM.

Practical value of this test

This test gives breeders a direct way to identify carriers before matings are planned. That matters because carriers can appear healthy but may produce affected puppies when paired with another carrier. The result supports targeted breeding selection, preservation of valuable lines through safe pairings and clear communication with puppy buyers. In young dogs from the relevant breed context, it also helps explain sudden heart failure or unexpected death genetically.