Hoof wall separation disease / HWSD (SERPINB11-related) - Horse

What does this test analyse?

This genetic test analyses the SERPINB11 c.504_505insC variant in horses. The condition is also known as Hoof Wall Separation Disease, HWSD, hoof wall separation syndrome and an inherited disorder of hoof horn integrity.

What does it mean for the horse?

HWSD affects the quality and attachment of the hoof wall. In affected horses, the weight-bearing hoof wall can separate, crumble or lack strength. This can cause pain, lameness, difficulty bearing weight and intensive hoof care needs. The condition is best known in Connemara ponies, but related or historically connected lines can also be relevant.

The test clarifies whether a horse is clear, carrier or has two copies of the HWSD variant. Carriers are usually healthy themselves but can pass the variant on. Identifying carriers helps breeders plan healthy matings without automatically excluding valuable bloodlines.

Practical value of this test

• Detects the known SERPINB11 c.504_505insC insertion.
• Helps identify carriers before breeding.
• Reduces the risk of foals with inherited hoof wall problems.
• Supports interpretation of hoof problems when HWSD occurs in the line.

Inheritance and result

HWSD is inherited as autosomal recessive. A horse with one copy is a carrier and passes the variant to about half of its offspring. Two copies cause HWSD and can lead to severe hoof wall abnormalities.