Hereditary hypothyroidism / congenital hypothyroidism 2 variants (TPO-related) - Cat

About hereditary hypothyroidism in cats

This DNA test assesses two variants in the TPO gene: c.1333G>A and c.430G>A. The condition is also known as hereditary hypothyroidism, congenital hypothyroidism, goiterous congenital hypothyroidism or thyroid dyshormonogenesis.

TPO encodes thyroid peroxidase, an enzyme required for thyroid hormone production. Reduced thyroid hormone production can clearly affect growth, metabolism, coat development and general vitality.

Key features

• Growth: delayed growth, disproportionate dwarfism or delayed skeletal development can occur.
• Coat and condition: persistent kitten-like coat, thin or matted hair, lethargy and weight gain may be seen.
• Thyroid gland: some cats develop an enlarged thyroid or goitre.

Practical value of this test

This TPO-related form is inherited as autosomal recessive. The result helps distinguish clear cats, carriers and genetically affected cats. Because the package tests two variants, it is especially useful for breeding plans and for recognising combinations that can produce at-risk kittens.