Hemophilia A / factor VIII deficiency (F8-related) - Boxer

What does this test examine?

This genetic test analyses the F8 c.1412C>G variant in the Boxer. The disorder is known as hemophilia A, factor VIII deficiency, FVIII deficiency and classical hemophilia. F8 is located on the X chromosome, so interpretation differs between males and females.

What does it mean for the dog?

Factor VIII is required for normal blood clotting. Males with the variant on their single X chromosome develop hemophilia A and can bleed for a long time or severely after injury, surgery, tooth eruption or sometimes spontaneously. Females with one copy are carriers and can pass the variant on; clotting activity may vary with X inactivation. This test clarifies genetic risk before breeding decisions or medical procedures.

Practical value of this test

• Breeders can identify carrier females and prevent the birth of affected males.
• The result helps manage hemophilia A in a line without losing valuable breeding lines unnecessarily.
• For dogs with the variant, the information matters when planning surgery, blood sampling, dentistry and wound care.

Hemophilia A is inherited as an X-linked recessive disorder. A male with the variant allele is affected; a female with one copy is a carrier and can pass the variant to offspring.