Exercise-induced metabolic myopathy / EIMM (ACADVL-related) - German Hunting Terrier

What does this test examine?

This genetic test analyses the ACADVL variant c.1728C>A for Exercise-induced metabolic myopathy in the German Hunting Terrier. The condition is also known as EIMM and ACADVL-related myopathy. The test determines whether the dog is clear, a carrier or genetically affected for this autosomal recessive variant.

What does this condition mean?

ACADVL is involved in muscle energy supply through fatty-acid metabolism. Dogs with the affected genotype can develop exercise-related muscle weakness, muscle pain, exercise intolerance and dark urine caused by muscle damage. This makes the test relevant for working, hunting and sporting dogs where physical activity is central.

Inheritance and result

The condition is inherited as autosomal recessive. A dog with C/C does not carry the variant. A dog with C/A is a carrier and can pass the variant on. A dog with A/A has two copies and develops the tested inherited form of EIMM.

Practical value of this test

• helps breeders identify carriers in German Hunting Terrier lines
• supports mating plans and helps prevent affected puppies
• gives owners clear information about exercise-related muscle problems
• supports selection with attention to health, usability and performance