Early Onset Progressive Polyneuropathy / EOPP / Greyhound Polyneuropathy (NDRG1-related) - Greyhound

What does this test examine?

This genetic test analyses the NDRG1 variant c.1080_1089del10 for Early Onset Progressive Polyneuropathy in the Greyhound. The condition is also known as EOPP, Greyhound Polyneuropathy, GHPN and juvenile Greyhound polyneuropathy. The test determines whether the dog is clear, a carrier or genetically affected for this autosomal recessive variant.

What does this condition mean?

EOPP is an inherited neurological disorder in which the peripheral nerves do not function properly. In affected young Greyhounds, first signs may appear from about three to nine months of age. Typical signs include exercise intolerance, abnormal gait, high-stepping movement, trembling or collapse after activity, progressive muscle weakness, ataxia, voice changes and, in severe cases, breathing difficulties.

Inheritance and result

The condition is inherited as autosomal recessive. A dog with N/N does not carry the variant. A dog with N/del is a carrier and can pass the variant to offspring. A dog with del/del has two copies and develops the tested inherited form of Greyhound polyneuropathy.

Practical value of this test

• enables targeted breeding selection in Greyhound lines where EOPP is relevant
• helps identify carriers before they are unknowingly used in breeding combinations
• supports mating plans that avoid carrier-to-carrier pairings
• gives clarity for young dogs or family lines with neurological history