Early-onset adult deafness / EOAD (EPS8L2-related) - Rhodesian Ridgeback

What does this test examine?

This genetic test analyses the EPS8L2 variant c.1033_1044del for early-onset adult deafness in the Rhodesian Ridgeback. The condition is also referred to as EOAD and sometimes EAOD. The test determines whether the dog is clear, a carrier or genetically affected for this autosomal recessive in-frame deletion.

What does this condition mean?

EOAD is an inherited form of progressive hearing loss. Puppies are not typically born deaf, but affected dogs may gradually lose hearing from a young age. In Rhodesian Ridgebacks, hearing loss is often noticed during the first years of life, sometimes from a few months of age and commonly within one to two years. Appearance and pigmentation can remain normal, making DNA information practically valuable.

Inheritance and result

The condition is inherited as autosomal recessive. A dog with N/N does not carry the variant. A dog with N/del is a carrier and can pass it to offspring. A dog with del/del has two copies and develops the tested inherited form of early-onset adult deafness.

Practical value of this test

• helps breeders identify carriers early in Rhodesian Ridgeback lines
• makes mating choices clearer and helps prevent affected puppies
• supports planning in lines where hearing loss or EOAD status matters
• gives owners useful clarity when hearing changes are noticed in young dogs