Turnaround time
10 workdays
48.4
40
DNA test for four PAX3 variants that can cause dominant blue eyes, heterochromia and minimal white spotting in cats.
Overview
This genetic test analyses four variants in PAX3 involved in dominant blue eyes, also known as DBE. The trait may appear as two blue eyes, one blue and one pigmented eye, or partly coloured eyes, often together with minimal to more visible white spotting.
PAX3 is involved in pigment-cell development. Variants in this gene can influence pigmentation of the iris, skin and coat. Deafness has been described or suspected in certain DBE lines, while other variants are less linked with deafness in heterozygous cats.
We welcome reference samples from cats with clear dominant blue eyes, heterochromia or related markings, especially when none of the tested variants is found. These samples help identify additional causal variants for this trait and refine the test further.
Included subanalyses
This analysis includes the following subanalyses:
Allele combinations & result interpretations
Below, for each tested locus, you will find the possible allele combinations that may be reported within this analysis, together with a brief explanation of their genetic meaning. The interpretation of possible interactions between different loci is included in the report, but is not shown here in full because that would lead to too many combinations on this page. The final expression may also depend on other genes and their interaction.
Genotype / allele combination: Clear for the tested variant
This cat does not carry the tested PAX3 variant. This variant will not cause the tested trait in this cat and will not be passed on.
Genotype / allele combination: Carrier of the dominant variant
This cat carries one copy of the tested PAX3 variant. One copy can cause the tested dominant trait and can be passed to offspring.
Genotype / allele combination: Two copies of the dominant variant
This cat has two copies of the tested PAX3 variant. For a dominant variant this is interpreted as genetically affected; visible expression and health impact can differ by variant.
Genotype / allele combination: Clear for the tested variant
This cat does not carry the tested PAX3 variant. This variant will not cause the tested trait in this cat and will not be passed on.
Genotype / allele combination: Carrier of the dominant variant
This cat carries one copy of the tested PAX3 variant. One copy can cause the tested dominant trait and can be passed to offspring.
Genotype / allele combination: Two copies of the dominant variant
This cat has two copies of the tested PAX3 variant. For a dominant variant this is interpreted as genetically affected; visible expression and health impact can differ by variant.
Genotype / allele combination: Clear for the tested variant
This cat does not carry the tested PAX3 variant. This variant will not cause the tested trait in this cat and will not be passed on.
Genotype / allele combination: Carrier of the dominant variant
This cat carries one copy of the tested PAX3 variant. One copy can cause the tested dominant trait and can be passed to offspring.
Genotype / allele combination: Two copies of the dominant variant
This cat has two copies of the tested PAX3 variant. For a dominant variant this is interpreted as genetically affected; visible expression and health impact can differ by variant.
Genotype / allele combination: Clear for the tested variant
This cat does not carry the tested PAX3 variant. This variant will not cause the tested trait in this cat and will not be passed on.
Genotype / allele combination: Carrier of the dominant variant
This cat carries one copy of the tested PAX3 variant. One copy can cause the tested dominant trait and can be passed to offspring.
Genotype / allele combination: Two copies of the dominant variant
This cat has two copies of the tested PAX3 variant. For a dominant variant this is interpreted as genetically affected; visible expression and health impact can differ by variant.
Sampling and submission guidelines





References