Turnaround time
10 workdays
48.4
40
DNA test for the MYO7A c.3719G>A variant that causes deafness with vestibular dysfunction / DINGS2 in Doberman Pinschers.
Overview
This genetic test detects the MYO7A c.3719G>A variant that causes deafness with vestibular dysfunction. The condition is also described as DVD, DINGS2, deafness with vestibular dysfunction or an inherited form of deafness with balance problems.
MYO7A is important for function of hair cells in the inner ear. Affected puppies can be deaf and show clear vestibular problems, such as head tilt, loss of balance, circling or uncoordinated movement. Signs are often visible early in life.
DVD/DINGS2 caused by this MYO7A variant follows an autosomal recessive inheritance pattern. Two copies cause the disease; one copy makes the dog a carrier.
Included subanalyses
This analysis includes the following subanalysis:
Allele combinations & result interpretations
Below, for each tested locus, you will find the possible allele combinations that may be reported within this analysis, together with a brief explanation of their genetic meaning. The interpretation of possible interactions between different loci is included in the report, but is not shown here in full because that would lead to too many combinations on this page. The final expression may also depend on other genes and their interaction.
Genotype / allele combination: Clear / no tested variant (GG)
The dog does not carry the tested variant. This genotype does not cause deafness with vestibular dysfunction / DINGS2 and will not pass this variant to offspring.
Genotype / allele combination: Carrier / one copy (GA)
The dog carries one copy of the tested variant. One copy does not cause deafness with vestibular dysfunction / DINGS2, but the variant can be passed on. Mate carriers only to dogs tested clear.
Genotype / allele combination: Affected / two copies (AA)
The dog carries two copies of the tested variant. This genotype causes deafness with vestibular dysfunction / DINGS2; the dog will pass the variant to all offspring.
Sampling and submission guidelines





References