Dandy-Walker-like malformation / cerebellar hypoplasia / DWLM (VLDLR-related) - Eurasier

What does this test detect?

This genetic test analyses the VLDLR variant c.1713delC in the Eurasier. The variant is used for Dandy-Walker-like malformation, DWLM, cerebellar hypoplasia, CH and inferior cerebellar hypoplasia.

What does this mean for the dog?

In this condition, part of the cerebellum does not develop normally. The cerebellum is important for coordination, balance and precise movement. Affected puppies may therefore show signs around the time they start walking, including an unsteady gait, falling or rolling, tremor, exaggerated limb movement, balance problems and reduced menace response.

The condition is described as non-progressive ataxia: the neurological basis is present from a young age and severity differs between dogs. Some dogs improve functionally as they mature, while others remain clearly uncoordinated. Because the visible signs can resemble other neurological or developmental problems, a DNA result gives useful clarity about the inherited cause.

Inheritance and result

The VLDLR variant follows autosomal recessive inheritance. A dog with two copies develops the condition. A dog with one copy is usually clinically clear for this variant but can pass it to offspring. Two carriers can produce affected puppies together.

Practical value of this test

• The test helps Eurasier breeders identify carriers before choosing a mating.
• The result supports selection of combinations that do not produce puppies affected by this variant.
• In young dogs with ataxia or balance problems, the test helps confirm or exclude a targeted inherited cause.
• For lines in which DWLM, CH or related neurological signs occur, the test makes risk management more concrete and easier to plan.