Cerebellar cortical degeneration / NCCD (SNX14-related) - Vizsla

What does this test analyse?

This genetic test analyses the SNX14 variant c.2653+1G>A in the Vizsla. The condition is known as cerebellar cortical degeneration, CCD, neonatal cortical cerebellar degeneration, NCCD and cerebellar abiotrophy.

What does this mean for the dog?

CCD/NCCD affects the cerebellum, the brain region important for coordination, balance and fine motor control. Affected Vizslas can develop progressive ataxia, exaggerated movements, wide stance, trunk sway, intention tremors, head tilt, nystagmus and loss of coordination from a young age.

Practical value of this test

• Breeders can distinguish clear dogs, carriers and genetically affected dogs before planning matings.
• The result helps avoid carrier x carrier matings and directly lowers the risk of puppies with this inherited disorder.
• Valuable carriers can remain in the population responsibly by combining them only with clear partners.
• In puppies or young dogs with matching signs, the test provides a concrete genetic explanation that supports rapid follow-up.
• The test helps separate an inherited cause from other causes with similar symptoms.

Inheritance and interpretation

The trait is autosomal recessive. G/G means the tested variant was not detected. G/A means carrier. A/A causes cerebellar cortical degeneration / NCCD and is reported as a genetically affected result.