C-locus albinism c/c2 (TYR-related) - Cat

C-locus albinism in cats

This genetic test detects two TYR variants at the C locus: c.939del and c.1204C>T. These alleles are used for complete albinism and are also described as c, c2, oculocutaneous albinism type 1 or OCA1. TYR encodes tyrosinase, a key enzyme for melanin production.

What does C-locus albinism mean?

When a cat carries two complete albino alleles, pigment production is strongly or completely disrupted. This can result in a very pale or white coat, pale skin and altered eye pigmentation. Other coat-colour genes still influence the final appearance, but without functional TYR activity normal pigment cannot be built properly.

Why this test is useful

• The test detects two known TYR albino alleles in one analysis.
• The result helps distinguish clear cats, carriers and albino genotype combinations.
• Breeders can plan C-locus combinations with colourpoint, mink, Burmese and albino more accurately.

The alleles are inherited as autosomal recessive: one copy means carrier status, while two albino alleles cause albinism.