Beta-mannosidosis / lysosomal storage disease (MANBA-related) - German Shepherd Dog

Beta-mannosidosis in German Shepherd Dogs

This genetic test detects the MANBA c.560T>A variant that causes beta-mannosidosis in German Shepherd Dogs. The condition is also described as beta-mannosidase deficiency, MANBA-related beta-mannosidosis or an inherited lysosomal storage disease.

What does this mean for the dog?

MANBA encodes beta-mannosidase, an enzyme needed for breakdown processes in lysosomes. In affected dogs, breakdown products accumulate and mainly affect development and the nervous system. Signs can include poor growth, behavioural or learning problems, balance problems, tremors and progressive neurological decline.

Practical value of this test

• Identifies clear dogs, carriers and genetically affected animals.
• Helps breeders avoid carrier-to-carrier matings.
• Supports early genetic clarity in German Shepherd lines.

Inheritance

Beta-mannosidosis caused by this MANBA variant follows an autosomal recessive inheritance pattern. Two copies cause the disease; one copy makes the dog a carrier.