Bernard-Soulier syndrome / BSS Cocker Spaniel type (GP9-related) - English Cocker Spaniel

Bernard-Soulier syndrome in Cocker Spaniels

This genetic test detects the GP9 c.127_*2052del deletion that causes Bernard-Soulier syndrome. The condition is also known as BSS, macrothrombocytopenia or an inherited platelet disorder of the Cocker Spaniel type.

What does this mean for the dog?

GP9 forms part of the platelet receptor complex needed for normal blood clotting. Affected dogs have large, poorly functioning platelets and an increased tendency to bleed. This can appear as bruising, nosebleeds, prolonged bleeding after injury, dental procedures or surgery.

Practical value of this test

• Identifies clear dogs, carriers and genetically affected animals.
• Helps breeders avoid carrier-to-carrier matings.
• Provides valuable information for breeding, surgery planning and bleeding-risk management.

Inheritance

This form of BSS follows an autosomal recessive inheritance pattern. Two copies of the deletion cause the disease; one copy makes the dog a carrier.