Acute respiratory distress syndrome / ARDS (ANLN-related) - Dalmatian

What does this test examine?

This genetic test examines the ANLN c.31C>T variant in Dalmatians. The condition is known as acute respiratory distress syndrome, ARDS, respiratory distress syndrome, RDS or shock lung.

What does this mean for the dog?

ANLN plays a role in the organisation of epithelial cells in lung tissue. Dogs with two copies of the variant can develop a severe inherited lung disorder with rapid breathing, shortness of breath, cyanosis and progressive respiratory problems. The condition is mainly described in young Dalmatians and can progress quickly.

Practical value of this test

• The test helps identify clear dogs, carriers and genetically affected dogs.
• Breeders can avoid pairings that may produce affected puppies.
• In Dalmatians, the result provides valuable information for breeding selection and for understanding familial respiratory disease.

The condition is inherited as an autosomal recessive trait. Carriers have one copy and pass the variant to some offspring; dogs with two copies have the genetic risk profile for ARDS.