Skeletal dysplasia 2 / SD2 (COL11A2-related) - Labrador Retriever

What does this test examine?

This genetic test analyses the COL11A2 variant c.143G>C in the Labrador Retriever. The trait is known as skeletal dysplasia 2, SD2, disproportionate dwarfism, short-legged syndrome and Labrador Retriever type disproportionate dwarfism.

What does SD2 mean?

SD2 affects cartilage and bone development. Affected dogs typically have shorter limbs with a relatively normal trunk and head. The difference can be subtle in young dogs, but is important for breeding selection, line management and identifying the genetic cause of short legs.

Inheritance and result

The trait is autosomal recessive. Clear dogs do not carry the tested variant, carriers have one copy and dogs with two copies develop the SD2 genotype. Carriers can be managed effectively through targeted mate selection.

Practical value of this test

• Breeders can reliably identify carriers and avoid affected combinations.
• The result helps explain short limbs or altered body proportions genetically.
• Targeted selection lowers risk while keeping valuable breeding animals available.