Shar-Pei autoinflammatory disease / SPAID / Familial Shar-Pei fever (MTBP-related) - Chinese Shar-Pei

What does this test examine?

This genetic test analyses the MTBP variant c.2623G>A in the Chinese Shar-Pei. The condition is known as Shar-Pei autoinflammatory disease, SPAID, familial Shar-Pei fever, FSF, recurrent fever syndrome and swollen hock syndrome.

What does SPAID mean?

SPAID is an inherited tendency toward excessive inflammatory responses. Dogs with increased genetic risk may show recurring fever episodes, painful or swollen hocks, skin and ear inflammation and other inflammatory signs. In sensitive dogs, persistent inflammation can also contribute to amyloidosis and kidney problems.

Inheritance and result

SPAID has a multifactorial genetic component. The test shows whether the dog carries zero, one or two copies of the tested MTBP variant. More copies increase genetic predisposition, while severity and age of onset can differ between dogs.

Practical value of this test

• Breeders can plan matings more consciously and follow lines with inflammatory problems more closely.
• Owners receive clear information about genetic predisposition for SPAID-like signs.
• The result helps place fever, swelling and inflammatory signs in the Chinese Shar-Pei in a useful genetic context.