Primary open-angle glaucoma / POAG (ADAMTS10-related) - Beagle

What does this test examine?

This genetic test analyses the ADAMTS10 variant c.1981G>A in the Beagle. The condition is known as primary open-angle glaucoma / POAG, hereditary glaucoma and inherited open-angle glaucoma. In POAG, the drainage angle of the eye remains open, but aqueous fluid does not drain effectively. Eye pressure can rise gradually and damage the retina and optic nerve.

What does this condition mean?

Glaucoma is a serious eye disease that can cause pain, redness, corneal cloudiness, enlarged eyes and progressive loss of vision. Early changes may be subtle, so inherited glaucoma is often noticed only after clear eye damage has developed. DNA testing makes it possible to identify the genetic risk before visible signs appear.

• Clear: the dog does not carry the tested variant.
• Carrier: the dog carries one copy and can pass the variant to offspring.
• Affected: two copies cause the tested inherited eye risk in this breed.

Practical value of this test

This analysis is especially useful for breeders who want to include eye health in selection decisions. The result helps identify carriers, avoid high-risk matings and preserve valuable lines without excluding dogs unnecessarily. For owners, it provides clear genetic information that supports targeted eye follow-up and a better understanding of family or line-related risk.

• Supports informed breeding plans in the Beagle.
• Helps avoid combinations that can produce puppies with two copies of the variant.
• Separates clear dogs, carriers and dogs with the affected genotype.
• Adds useful context for eye examinations, family history and selection of breeding animals.

Inheritance and interpretation

The trait is inherited in an autosomal recessive manner. A carrier is usually not affected, but can pass the variant on. When two carriers are bred together, some puppies can inherit two copies and develop the inherited glaucoma risk. Age of onset and severity can differ between dogs, but the DNA result gives a direct and lifelong indication of the tested inherited predisposition.