Norwich Terrier Upper Airway Syndrome / NTUAS (ADAMTS3-related) - Norwich Terrier

NTUAS in the Norwich Terrier

This genetic test detects the ADAMTS3 c.2786G>A variant used in the Norwich Terrier as a genetic risk marker for Norwich Terrier Upper Airway Syndrome. The condition is also known as NTUAS, UAS or upper airway syndrome.

What does this mean for the dog?

NTUAS can cause noisy breathing, snoring or snorting, exercise difficulty and narrowing of the upper airway. In affected dogs, extra throat tissue, laryngeal changes and partial laryngeal collapse can contribute to the clinical picture.

Practical value of this test

• Gives breeders genetic information about an important airway trait in Norwich Terriers.
• Distinguishes dogs with zero, one or two copies of the ADAMTS3 risk variant.
• Supports more targeted mating choices and follow-up of airway sensitivity within breeding lines.

Inheritance and result

The inheritance model is not described as a simple classical Mendelian pattern. G/G means the tested risk variant was not detected, G/A means one copy and A/A means two copies of the tested ADAMTS3 variant.