Turnaround time
10 workdays
48.4
40
DNA test for the MSTN c.939_940delTG variant in Whippets, known for muscular hypertrophy, double muscling, myostatin deficiency and the Bully Whippet phenotype.

Overview
This DNA test analyses the MSTN variant c.939_940delTG in Whippets. The trait is known as muscular hypertrophy, double muscling, myostatin deficiency, hypermuscularity and Bully Whippet syndrome.
MSTN encodes myostatin, a negative regulator of muscle growth. The deletion reduces this brake on muscle development. Whippets with one copy often have noticeably increased musculature compared with dogs without the variant. Dogs with two copies develop the pronounced Bully Whippet or double muscling phenotype, with a broad chest, powerful neck and leg muscles and a very muscular build.
The result helps Whippet breeders plan muscle development, sport lines and breeding combinations more accurately. It shows which dogs carry the variant, which dogs have two copies and which matings can produce Bully Whippet offspring.
Included subanalyses
This analysis includes the following subanalysis:
Allele combinations & result interpretations
Below, for each tested locus, you will find the possible allele combinations that may be reported within this analysis, together with a brief explanation of their genetic meaning. The interpretation of possible interactions between different loci is included in the report, but is not shown here in full because that would lead to too many combinations on this page. The final expression may also depend on other genes and their interaction.
Genotype / allele combination: Clear TG/TG
The dog does not carry the tested MSTN deletion. This result does not cause MSTN-related extra muscularity and the variant is not passed on.
Genotype / allele combination: One copy TG/delTG
The dog carries one copy of the MSTN deletion. This usually causes more muscle development than in clear dogs and the variant can be passed to offspring.
Genotype / allele combination: Double muscling delTG/delTG
The dog has two copies of the MSTN deletion. This causes the pronounced double muscling or Bully Whippet phenotype with very strong muscle development.
Sampling and submission guidelines





References