Mulefoot / Syndactyly / MF (LRP4-related) - Cattle

Mulefoot and syndactyly in cattle

This DNA test examines the Holstein-Friesian LRP4 variant c.4863_4864delinsAT that causes mulefoot. The trait is also known as syndactyly, MF, MFD, SY or HHM. In syndactyly, the normally separated claws are partly or fully fused.

What does mulefoot mean?

• Hoof shape: one or more feet can develop a single hoof-like form.
• Movement: the defect can affect standing, walking and load on the limbs.
• Variation: severity and number of affected limbs can differ between animals.

Practical value of this test

The result helps Holstein-Friesian breeders distinguish clear animals, carriers and genetically affected animals. Because carriers are usually normal, DNA testing makes it possible to manage the LRP4 variant and avoid risk matings.