Lethal acrodermatitis / LAD (MKLN1-related) - Bull Terrier type

What does this test examine?

This genetic test analyses the MKLN1 variant c.400+3A>C in the Bull Terrier en Miniatuur Bull Terrier. The condition is known as lethal acrodermatitis / LAD, also called LAD, lethal acrodermatitis, acrodermatitis and MKLN1-related acrodermatitis.

LAD is a severe puppy disorder with skin lesions, abnormal nails, recurring infections, diarrhoea and poor growth. Affected dogs often have a serious life-limiting condition.

Practical value of this test

• reveals carriers before two carriers are mated;
• helps prevent the birth of severely affected puppies;
• supports responsible preservation of breeding lines by planning carrier matings safely;
• gives puppy buyers and breed clubs clear information about LAD status.

Who benefits from this test?

For Bull Terrier lines this DNA test is highly practical because carriers can be healthy themselves but together produce affected puppies. By pairing carriers with clear-tested partners, selection remains possible without unnecessarily losing valuable lines.

• for breeders who want to know inherited risks before planning a mating;
• for owners who want clarity about their dog’s genetic status;
• for veterinarians and breed clubs who want structured breed-health information;
• for puppy buyers who value transparent inherited-health information within a line.

Inheritance and result meaning

LAD is inherited as an autosomal recessive disorder: two copies cause disease, while one copy means carrier status. Consistent use of test results makes it possible to greatly reduce LAD risk.