Laryngeal paralysis / LP risk variant (RAPGEF6-related) - Bull Terrier type

What does this test examine?

This genetic test analyses the RAPGEF6 variant c.1793_1794ins36 in the Bull Terrier en Miniatuur Bull Terrier. The condition is known as laryngeale verlamming / LP, also called LP, laryngeal paralysis and Bull Terrier-type laryngeal paralysis.

Laryngeal paralysis limits opening of the larynx during inspiration. Affected or high-risk dogs may breathe noisily, become short of breath more easily and tolerate exercise poorly.

Practical value of this test

• helps identify dogs with increased genetic risk early;
• makes breeding selection more targeted in Bull Terriers and Miniature Bull Terriers;
• reduces the chance of unknowingly combining two risk-carrying lines;
• provides practical information for planning, follow-up and breeder communication.

Who benefits from this test?

This test is useful when breeders want to look beyond visible breathing signs and understand genetic predisposition within a line. Because this is a risk variant, the result is mainly used to plan matings and follow-up more intelligently.

• for breeders who want to know inherited risks before planning a mating;
• for owners who want clarity about their dog’s genetic status;
• for veterinarians and breed clubs who want structured breed-health information;
• for puppy buyers who value transparent inherited-health information within a line.

Inheritance and result meaning

This marker belongs to a multifactorial condition: two copies clearly increase risk, but the result is not a simple all-or-nothing prediction. Use the result as strong genetic risk information, together with breed, family history and clinical follow-up.