Factor VII deficiency / FVIID (F7-related) - Dog

What does this test examine?

This genetic test analyses the F7 variant c.407G>A for Factor VII deficiency in dogs. The condition is also known as FVII deficiency, FVIID, congenital Factor VII deficiency, proconvertin deficiency and hypoproconvertinaemia. The test determines whether the dog is clear, a carrier or genetically affected for this autosomal recessive variant.

What does this condition mean?

Factor VII is important for blood clotting. Dogs with the affected genotype can show prolonged prothrombin time, mild to moderate bleeding tendency, bruising and excessive bleeding after trauma, surgery or whelping. Severity can differ between dogs, but the DNA result makes the inherited risk clear.

Inheritance and result

The condition is inherited as autosomal recessive. A dog with G/G does not carry the variant. A dog with G/A is a carrier and can pass the variant on. A dog with A/A has two copies and develops the tested inherited form of Factor VII deficiency.

Practical value of this test

• helps breeders identify carriers before they are used in breeding combinations
• supports mating plans and helps prevent affected puppies
• provides useful information in breeds or lines where bleeding tendency is relevant
• helps owners and veterinarians take increased bleeding risk into account around injury, surgery or whelping