Exfoliative cutaneous lupus erythematosus / ECLE (UNC93B1-related) - pointing dogs and Vizsla

What does this test examine?

This genetic test analyses the UNC93B1 variant c.1438C>A for exfoliative cutaneous lupus erythematosus in dogs. The condition is also known as ECLE and chronic cutaneous lupus. The test determines whether the dog is clear, a carrier or genetically affected for this autosomal recessive variant.

What does this condition mean?

ECLE is an inherited skin disease in which dogs can develop scaling, crusting, redness, hair loss and secondary skin infections. In some dogs the disease can become more severe and may also involve discomfort or joint-related signs. The test is especially relevant in affected pointing-dog and Vizsla lines where this variant occurs.

Inheritance and result

The condition is inherited as autosomal recessive. A dog with C/C does not carry the variant. A dog with C/A is a carrier and can pass the variant on. A dog with A/A has two copies and develops the tested inherited form of ECLE.

Practical value of this test

• helps breeders identify carriers in relevant breeds and lines
• supports mating plans and helps prevent affected puppies
• supports selection for skin health without unnecessarily excluding valuable lines
• gives owners clear information when skin problems or breed-related risk are relevant