E. coli diarrhoea / oedema disease susceptibility (FUT1/F18 ETEC) - Pig

What does this test examine?

This DNA test analyses the FUT1 M307 variant in pigs, commonly referred to as c.307G>A. The modern transcript notation is ENSSSCT00000051297.2:c.304A>G. The test helps assess susceptibility or resistance to F18 ETEC and oedema disease.

The condition is also described as E. coli F18, F18 ETEC, ECF18R, F18 receptor, oedema disease, gut oedema, bowel oedema, post-weaning diarrhoea and F18-related E. coli diarrhoea.

Why is FUT1 important?

F18 ETEC can attach to the small intestine when the appropriate receptor is present. FUT1 M307 status influences this adhesion. Animals with the resistant A/A genotype have a more favourable protection profile against F18 adhesion, while G/G and G/A are interpreted as more susceptible.

Susceptible animals can develop diarrhoea, reduced growth, oedema disease, neurological signs and losses after exposure. The genetic result therefore supports both breeding selection and risk management in lines affected by F18 problems.

Practical value of this test

This test is valuable for farms aiming for more robust piglets around weaning and for breeding programmes that want to include F18 resistance structurally.

Why test?

• Distinguishes susceptible and more resistant FUT1 M307 genotypes.
• Helps strengthen resistance to F18 ETEC and oedema disease in breeding lines.
• Adds information in cases of recurring post-weaning diarrhoea, growth loss or mortality.
• Supports selection of animals with a less favourable receptor pattern for F18 attachment.
• Helps improve health, growth and production security around weaning.