Turnaround time
10 workdays
48.4
40
DNA panel for nine MSTN variants associated with Double Muscling or muscular hypertrophy in cattle.

Overview
Double Muscling, also known as muscular hypertrophy, is mainly associated in cattle with variants in the MSTN gene. Myostatin normally limits muscle development. Variants that reduce myostatin function can increase muscle mass and reduce fat deposition.
This analysis tests nine MSTN variants used in beef cattle selection: C313Y, nt419, E226*, nt821, E291*, Q204*, S105C, F94L and D182N. Disruptive variants are especially important for pronounced muscle hypertrophy and can be associated with higher birth weights and more calving difficulty. Missense variants can influence muscularity and fat distribution without the same strong birth-risk profile.
The result shows which variants are present and helps breeders manage muscle development, calving planning and breeding goals more precisely.
Included subanalyses
This analysis includes the following subanalyses:
Allele combinations & result interpretations
Below, for each tested locus, you will find the possible allele combinations that may be reported within this analysis, together with a brief explanation of their genetic meaning. The interpretation of possible interactions between different loci is included in the report, but is not shown here in full because that would lead to too many combinations on this page. The final expression may also depend on other genes and their interaction.
Genotype / allele combination: No C313Y allele detected
The C313Y allele was not detected in this subanalysis. This animal does not pass on this specific allele.
Genotype / allele combination: One C313Y allele detected
One copy of the C313Y allele was detected. This animal produces this MSTN variant in combination with the other CSN2 allele and can pass C313Y to about half of its offspring.
Genotype / allele combination: Two C313Y alleles detected
Two copies of the C313Y allele were detected. This animal produces only this tested beta-casein variant and passes C313Y to all offspring.
Genotype / allele combination: No nt419 allele detected
The nt419 allele was not detected in this subanalysis. This animal does not pass on this specific allele.
Genotype / allele combination: One nt419 allele detected
One copy of the nt419 allele was detected. This animal produces this MSTN variant in combination with the other CSN2 allele and can pass nt419 to about half of its offspring.
Genotype / allele combination: Two nt419 alleles detected
Two copies of the nt419 allele were detected. This animal produces only this tested beta-casein variant and passes nt419 to all offspring.
Genotype / allele combination: No E226* allele detected
The E226* allele was not detected in this subanalysis. This animal does not pass on this specific allele.
Genotype / allele combination: One E226* allele detected
One copy of the E226* allele was detected. This animal produces this MSTN variant in combination with the other CSN2 allele and can pass E226* to about half of its offspring.
Genotype / allele combination: Two E226* alleles detected
Two copies of the E226* allele were detected. This animal produces only this tested beta-casein variant and passes E226* to all offspring.
Genotype / allele combination: No nt821 allele detected
The nt821 allele was not detected in this subanalysis. This animal does not pass on this specific allele.
Genotype / allele combination: One nt821 allele detected
One copy of the nt821 allele was detected. This animal produces this MSTN variant in combination with the other CSN2 allele and can pass nt821 to about half of its offspring.
Genotype / allele combination: Two nt821 alleles detected
Two copies of the nt821 allele were detected. This animal produces only this tested beta-casein variant and passes nt821 to all offspring.
Genotype / allele combination: No E291* allele detected
The E291* allele was not detected in this subanalysis. This animal does not pass on this specific allele.
Genotype / allele combination: One E291* allele detected
One copy of the E291* allele was detected. This animal produces this MSTN variant in combination with the other CSN2 allele and can pass E291* to about half of its offspring.
Genotype / allele combination: Two E291* alleles detected
Two copies of the E291* allele were detected. This animal produces only this tested beta-casein variant and passes E291* to all offspring.
Genotype / allele combination: No Q204* allele detected
The Q204* allele was not detected in this subanalysis. This animal does not pass on this specific allele.
Genotype / allele combination: One Q204* allele detected
One copy of the Q204* allele was detected. This animal produces this MSTN variant in combination with the other CSN2 allele and can pass Q204* to about half of its offspring.
Genotype / allele combination: Two Q204* alleles detected
Two copies of the Q204* allele were detected. This animal produces only this tested beta-casein variant and passes Q204* to all offspring.
Genotype / allele combination: No S105C allele detected
The S105C allele was not detected in this subanalysis. This animal does not pass on this specific allele.
Genotype / allele combination: One S105C allele detected
One copy of the S105C allele was detected. This animal produces this MSTN variant in combination with the other CSN2 allele and can pass S105C to about half of its offspring.
Genotype / allele combination: Two S105C alleles detected
Two copies of the S105C allele were detected. This animal produces only this tested beta-casein variant and passes S105C to all offspring.
Genotype / allele combination: No F94L allele detected
The F94L allele was not detected in this subanalysis. This animal does not pass on this specific allele.
Genotype / allele combination: One F94L allele detected
One copy of the F94L allele was detected. This animal produces this MSTN variant in combination with the other CSN2 allele and can pass F94L to about half of its offspring.
Genotype / allele combination: Two F94L alleles detected
Two copies of the F94L allele were detected. This animal produces only this tested beta-casein variant and passes F94L to all offspring.
Genotype / allele combination: No D182N allele detected
The D182N allele was not detected in this subanalysis. This animal does not pass on this specific allele.
Genotype / allele combination: One D182N allele detected
One copy of the D182N allele was detected. This animal produces this MSTN variant in combination with the other CSN2 allele and can pass D182N to about half of its offspring.
Genotype / allele combination: Two D182N alleles detected
Two copies of the D182N allele were detected. This animal produces only this tested beta-casein variant and passes D182N to all offspring.
Sampling and submission guidelines





References